Stereospecific high-performance liquid chromatographic analysis of warfarin in plasma.
J Pharm Sci
; 72(8): 921-4, 1983 Aug.
Article
em En
| MEDLINE
| ID: mdl-6620148
ABSTRACT
A stereospecific high-performance liquid chromatographic assay has been developed to determine R(+)- and S(-)-warfarin simultaneously in plasma. The method involved the formation of diastereoisomeric esters, using carbobenzyloxy-L-proline, with subsequent separation using silica as the stationary phase. The method permits characterization of the pharmacokinetics of warfarin enantiomers following administration of racemic drug.
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Base de dados:
MEDLINE
Assunto principal:
Varfarina
Limite:
Humans
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article