Plasma 10-hydroxynortriptyline in elderly depressed patients.
Clin Pharmacol Ther
; 35(4): 540-4, 1984 Apr.
Article
em En
| MEDLINE
| ID: mdl-6705454
ABSTRACT
Plasma concentrations of nortriptyline (NT) and of unconjugated E-10-hydroxynortriptyline (E-10-OH-NT) were measured under steady-state conditions in elderly (60 yr and older) and young adult (40 yr and younger) patients treated with NT. The two groups received equivalent doses of NT. Plasma NT concentrations of the two groups did not differ, but plasma E-10-OH-NT concentrations were higher in the elderly. The plasma E-10-OH-NT/NT ratios were twice as high in the elderly group. Plasma E-10-OH-NT/NT ratios varied 2000% between individuals in the elderly group but were stable within individuals. Plasma E-10-OH-NT/NT ratios correlated positively but weakly with serum creatinine concentrations.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Transtorno Depressivo
/
Nortriptilina
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article