[Hexahydroimidazo[1,5-a]-pyrazine. II. Synthesis of 7-phenyl-1,5,6,7,8,8a-hexahydroimidazo[,5-a]pyrazine-3(2H)-one and derivatives]. / Esaidroimidazo[1,5-a]pirazine. Nota II. Sintesi del 7-fenil-1,5,6,7,8,8a-esaidroimidazo[1,5-a]pirazin-3(2H)-one e derivati.
Farmaco Sci
; 39(5): 450-62, 1984 May.
Article
em It
| MEDLINE
| ID: mdl-6734819
ABSTRACT
The synthesis and activity on the central nervous system of a series of 2-aryl or 2-alkyl-7-phenylhexahydroimidazo[1,5-a] pyrazin-3(2H)-ones (II a-f) are reported. The intermediate 3-carbomethoxy-1-phenylpiperazine (X) was prepared in six steps from aniline and methyl-2-chloroacrylate. Compared with that of derivatives of Zetidoline, the depressant activity of (II a-f) is markedly reduced.
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Base de dados:
MEDLINE
Assunto principal:
Pirazinas
/
Depressores do Sistema Nervoso Central
Limite:
Animals
Idioma:
It
Ano de publicação:
1984
Tipo de documento:
Article