A 7-hydroxymethyl sulfate ester as an active metabolite of 7,12-dimethylbenz[alpha]anthracene.
Science
; 215(4531): 403-5, 1982 Jan 22.
Article
em En
| MEDLINE
| ID: mdl-6800033
ABSTRACT
7-Hydroxymethyl-12-methylbenz[alpha]anthracene (7-HMBA), a carcinogenic major metabolite of 7,12-dimethylbenz[alpha]anthracene (DMBA) in liver, was transformed by liver cytosolic sulfotransferase to reactive 7-HMBA sulfate, which is mutagenic toward Salmonella typhimurium strain TA98. The mutagenicity of 7-HMBA in the presence of hepatic sulfotransferase was much higher than that of DMBA or 7-HMBA in the presence of hepatic monooxygenase.
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Base de dados:
MEDLINE
Assunto principal:
Benzo(a)Antracenos
/
9,10-Dimetil-1,2-benzantraceno
/
Mutagênicos
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article