Mutagenesis in spermatozoa of Drosophila melanogaster by cross-linking agents depends on the mus(1)101+ gene product in the oocyte.
Mutat Res
; 95(2-3): 237-49, 1982 Aug.
Article
em En
| MEDLINE
| ID: mdl-6811888
ABSTRACT
In Drosophila melanogaster the sex-linked gene must(1)101+ is essential for mutagenesis induced by a cross-linking agent mature sperm mutagenized by nitrogen mustard (HN2) yield high frequencies of induced sex-linked recessive lethals if tested with wild-type oocytes but practically no recessive lethals if tested with homozygous mus(1)101D1 oocytes. In the absence of mus(1)101+ at least some cross-links act as lethal lesions, whereas in the presence of mus(1)101+ some act as premutational lesions. The lack of delayed mutations in mutant oocytes indicates that the lesions are efficiently eliminated and do not lead to mutagenesis in later post-fertilization nuclear divisions. The mutation mus(1)101D1 is not a null allele because, in tests with heterozygotes, it reduces mutagenesis to a lesser extent than a deletion including the mus(1)101 locus. It is a leaky allele with such a reduced activity that, in homozygous condition, mutagenesis is practically absent. In deletion heterozygotes the mus(1)101+ gene is not dosage-compensated.
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Base de dados:
MEDLINE
Assunto principal:
Drosophila melanogaster
/
Alelos
/
Genes Letais
/
Genes Recessivos
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article