Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat.
Science
; 219(4587): 975-7, 1983 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-6823559
ABSTRACT
Weekly transfusions of whole blood from a nondiabetic subline of BB/W rats reduced the incidence of diabetes in susceptible BB/W rats from 39 to 0 percent and the incidence of pancreatic insulitis from 64 to 6 percent. Responsiveness of lymphocytes to concanavalin A was found to be low in rats with diabetes or insulitis. Transfusion restored concanavalin A responsiveness to levels observed in control rats free of diabetes or insulitis. These data suggest that whole blood alters the course of autoimmune BB/W rat diabetes.
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Base de dados:
MEDLINE
Assunto principal:
Transfusão de Sangue
/
Diabetes Mellitus Experimental
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article