Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis.
Ann Intern Med
; 98(3): 327-30, 1983 Mar.
Article
em En
| MEDLINE
| ID: mdl-6830075
ABSTRACT
Thirteen reports of patients who developed polymyositis or dermatomyositis during treatment with D-penicillamine are reviewed and a fourteenth case is described. Twelve of the fourteen patients recovered after D-penicillamine was withdrawn; two patients died from cardiac involvement. Proximal muscle weakness was present in 13 patients and dermatomyositis in 4 patients. Dysphagia was the presenting symptom in 6 patients. Although D-penicillamine is useful in the management of rheumatoid arthritis, this drug should be used with caution and patients monitored closely for evidence of polymyositis or dermatomyositis.
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Base de dados:
MEDLINE
Assunto principal:
Penicilamina
/
Artrite Reumatoide
/
Miosite
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article