Inhibitors of gastric acid secretion: antisecretory 2-pyridylurea derivatives.
J Med Chem
; 26(4): 538-44, 1983 Apr.
Article
em En
| MEDLINE
| ID: mdl-6834386
ABSTRACT
A series of aminoalkyl-substituted pyridylureas has been prepared and evaluated as inhibitors of gastric acid secretion. N,N-Dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)urea (8g) was the most potent example of the class. Comparison of this compound with cimetidine showed it to be equipotent in dogs stimulated with gastrin tetrapeptide but approximately half as potent in dogs stimulated with histamine. Inhibition of secretion does not appear to result from antagonism of the histamine H2 receptor, since the compounds show only weak inhibition of the H2 receptor in vitro.
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Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Ureia
/
Ácido Gástrico
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article