Complexes between HBsAg and IgM in serum of patients with acute hepatitis.
J Med Virol
; 11(2): 139-45, 1983.
Article
em En
| MEDLINE
| ID: mdl-6842192
ABSTRACT
HBsAg bound to IgM was measured in the serum of HBsAg carriers with acute hepatitis using a radioimmunoassay based on selective absorption of IgM on solid phase coated with antiserum to human IgM. HBsAg/IgM was detected in 94 (100%) patients with acute type B hepatitis during the acute phase of infection and persisted after the fourth week only in 13 of them, who developed chronic liver disease. HBsAg/IgM was detected only in 1 patient out of 15 carriers of the HBsAg with superimposed non-B hepatitis. No activity was found in serum of 20 patients with acute HBsAg-negative hepatitis. The nature of the IgM component of the complex is uncertain, however, blocking experiments of the HBsAg/IgM reaction with polymerized human albumin suggest that the IgM component of the complex might represent antibody to the denatured protein. Persistent HBsAg/IgM complex detection in patients with acute type B hepatitis provides a useful tool to predict transition of HBV infection to chronicity. Its absence in patients with acute HBsAg-positive hepatitis is indicative of non-B hepatitis in chronic carriers of the HBsAg.
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina M
/
Hepatite B
/
Antígenos de Superfície da Hepatite B
/
Complexo Antígeno-Anticorpo
Limite:
Humans
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article