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Effects of ibopamine on serum prolactin and growth hormone levels in hyperprolactinemic and acromegalic subjects.
Clin Pharmacol Ther ; 34(1): 74-8, 1983 Jul.
Article em En | MEDLINE | ID: mdl-6861440
The effects of oral doses (100, 200, and 400 mg) of a dopamine derivative, ibopamine, on serum prolactin (PRL) and growth hormone (GH) levels were evaluated in hyperprolactinemic patients, some of whom also were acromegalic. There was dose-related lowering of PRL levels. The highest dose was as effective as 500 mg L-dopa, although the duration of action was shorter, with a decrease to below 50% of basal PRL values in all patients. Serum GH did not rise in nonacromegalic subjects, but it fell after 400 mg ibopamine in the L-dopa-sensitive acromegalic patients. These data suggest, but do not prove, that ibopamine is able to directly stimulate pituitary dopamine receptors.
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Base de dados: MEDLINE Assunto principal: Prolactina / Acromegalia / Hormônio do Crescimento / Dopamina / Desoxiepinefrina Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1983 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Prolactina / Acromegalia / Hormônio do Crescimento / Dopamina / Desoxiepinefrina Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1983 Tipo de documento: Article