Trimipramine and duodenal ulcer.
Scand J Gastroenterol Suppl
; 58: 71-8, 1980.
Article
em En
| MEDLINE
| ID: mdl-6929097
ABSTRACT
The gastric acid secretion, fasting serum gastrin and serum concentration of trimipramine were studied in 20 patients with duodenal ulcer during a 6 weeks treatment with trimipramine. Ulcer healing was examined endoscopically. In the group of 11 patients with healed ulcers the gastric acid secretion decreased significantly at 3 and 6 weeks in contrast to the 9 patients in whom ulcers did not heal, indicating a different antisecretory response in the two groups. The serum concentration of trimipramine was similar in both groups during treatment. Possible mechanisms of action of trimipramine in peptic ulcer disease and problems concerning clinical response and dose are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Trimipramina
/
Dibenzazepinas
/
Úlcera Duodenal
Limite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article