Evidence for involvement of mast cells in tumor suppression in mice.
J Natl Cancer Inst
; 69(6): 1305-9, 1982 Dec.
Article
em En
| MEDLINE
| ID: mdl-6982995
ABSTRACT
Mast cell-deficient W/Wv mice had an increased tumor incidence after subcutaneous treatment with 3-methylcholanthrene, compared with that in normal congenic mice treated in the same way. This increased tumor incidence was suppressed to the normal level when the carcinogen was given after the mast cell deficiency had been overcome by transplantation of bone marrow cells from normal congenic mice. The W/Wv mice, however, were not defective in natural killer and T-cell-mediated cytotoxic activities. These results support the hypothesis that mast cells are involved in tumor suppression.
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Base de dados:
MEDLINE
Assunto principal:
Mastócitos
/
Neoplasias
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article