Formation of mutagenic derivatives from nitrite and two primary amines.
Toxicol Lett
; 6(6): 379-83, 1980 Oct.
Article
em En
| MEDLINE
| ID: mdl-7003813
ABSTRACT
Sodium nitrite and two primary aromatic amines, viz. amino antipyrine (AAP) and aniline, were preincubated in vitro with human gastric juice. The resulting derivatives -- presumably diazonium salts -- were directly mutagenic in the Salmonella test. The mutagenic response was more pronounced in the case of AAP, while toxic effects narrowed the range of activity of the aniline derivative. These patterns are consistent with the findings of independent colorimetric analyses, showing that the AAP derivative is more stable at 37 degrees C than the aniline derivative.
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Base de dados:
MEDLINE
Assunto principal:
Nitrito de Sódio
/
Ampirona
/
Antipirina
/
Compostos de Diazônio
/
Compostos de Anilina
/
Mutagênicos
/
Nitritos
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article