Inhibition of the R3327MAT-Lu prostatic tumor by diethylstilbestrol and 1,2-bis(3,5-dioxopiperazin-1-yl)propane.
Cancer Res
; 42(4): 1390-4, 1982 Apr.
Article
em En
| MEDLINE
| ID: mdl-7060012
ABSTRACT
We have previously described the inhibitory effects of diethylstilbestrol on the growth of the androgen-independent, anaplastic Copenhagen rat prostatic tumor, R3327AT, which has a low metastatic potential. We have now selected a variant of the R3327AT tumor that metastasizes exclusively to the lungs, and we have designated it the R3327MAT-Lu. In a dose-response protocol, diethylstilbestrol was inhibitory to the primary R3327MAT-Lu tumor, thereby also inhibiting the formation of lung metastases. Inhibition was also observed in this model tumor by the chemotherapeutic agent 1,2-bis(3,5-dioxopiperazin-1-yl)propane.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Neoplasias da Próstata
/
Razoxano
/
Dietilestilbestrol
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article