Minimal nephrotoxicity with cephalosporin-aminoglycoside combinations in patients with neoplastic disease.
Antimicrob Agents Chemother
; 21(4): 592-4, 1982 Apr.
Article
em En
| MEDLINE
| ID: mdl-7081979
ABSTRACT
Patients with cancer and suspected sepsis were treated in a prospective, randomized trial with one of four cephalosporin-aminoglycoside combinations cephalothin and tobramycin; cephalothin and gentamicin; cefamandole and tobramycin; or cefamandole and gentamicin. Carbenicillin was added if the absolute granulocyte count was less than 1,000/mm3. Of 199 patients receiving 20 to more doses of an aminoglycoside and having serial determination of serum creatinines, nephrotoxicity developed in seven (3.5%) given any of the four combinations. There were no significant differences between patients receiving either cephalosporin or either aminoglycoside. Nephrotoxicity developed less frequently among children (2 or 125; 1.6%) than adults (5 of 74; 6.8%).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
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Cefalosporinas
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Nefropatias
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Antibacterianos
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Neoplasias
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Adult
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Aged
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Child
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Child, preschool
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Humans
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Infant
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Middle aged
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article