[Comparative evaluation of hydroxyproline in urine and in serum as a possible clinical parameter for radiation-induced destruction of connective tissue due to fractionated radiation therapy (author's transl)]. / Vergleichende Untersuchung über die Wertigkeit von Hydroxyprolin im Urin und im Serum als klinischer Parameter der radiogen bedingten Bindegewebsdestruktion unter fraktionierter Strahlentherapie.

ABSTRACT

In the course of postoperative fractionated radiation therapy hydroxyproline was evaluated as a biochemical parameter of radiation damage in 60 patients with different tumour diseases. At different times before, during and after therapy, hydroxyproline in serum was evaluated according to the method of Dabew and Struck, hydroxyproline in urine according to the test combination "hypronosticon" (Organon-Technika). There was no correlation to be found between hydroxyproline in serum or urine, clinical course of disease and radiation dose. Possible explanations were discussed.