Light-stimulated release of taurine from retinas of kainic acid-treated chicks.
J Neurochem
; 36(4): 1583-6, 1981 Apr.
Article
em En
| MEDLINE
| ID: mdl-7264653
ABSTRACT
The light-stimulated release of [3H]taurine from chick retina was studied in chicks intraocularly injected with kainic acid (60 nmol). This treatment produced a loss of more than 80% of the inner nuclear and the inner synaptic layers, sparing the outer retinal layers. Concomitantly, the treatment produced a marked decrease of endogenous GABA and glycine but not of taurine. The activity of glutamate decarboxylase was also markedly decreased in the kainic acid-treated retinas. The release of [3H]taurine, either spontaneous or stimulated by light, was unaffected by the treatment. These results suggest that the light-stimulated efflux of taurine occurs from the retinal layers which are not affected by the kainic acid treatment.
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Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Retina
/
Taurina
/
Ácido Caínico
/
Luz
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article