Protection by antibiotics against experimental focal cholangitis produced in mice by a schistosomicidal isothiocyanate.
Hepatology
; 1(1): 21-7, 1981.
Article
em En
| MEDLINE
| ID: mdl-7286888
ABSTRACT
Oral administration to mice of high doses of 4-isothiocyano-4'nitrodiphenylamine (amoscanate), a potent antischistosomal drug, produced focal necrotizing lesions of the large intrahepatic and extrahepatic bile ducts and the gallbladder. Coadministration of erythromycin and, to a somewhat lesser degree, of paromomycin, markedly reduced the effects of amoscanate on the biliary tract. These results suggest that amoscanate may be converted to a cholangiotoxic product by one or several constituents of the enteric bacterial flora. Since erythromycin does not affect the antischistosomal activity of amoscanate, coadministration of an antibacterial agent can reduce toxic effects of a drug while full chemotherapeutic activity is maintained. The possibility of toxic effects of metabolites of xenobiotics produced by intestinal bacteria deserves attention and the experimental production of focal intrahepatic and extrahepatic cholangitis by such drug metabolites suggests a possible mechanism in human bile diseases.
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Base de dados:
MEDLINE
Assunto principal:
Esquistossomicidas
/
Tiocianatos
/
Colangite
/
Isotiocianatos
/
Difenilamina
/
Compostos de Anilina
/
Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article