Effects of tienilic acid used alone and in association with triamterene or amiloride on urinary excretion of electrolytes.

ABSTRACT

The K-sparing effects of amiloride (A) and triamterene (T) associated with tienilic acid (C) are studied, along with their effects on diuresis and on the urinary excretion of uric acid, Mg, Na, Cl, P, and Ca. Eighteen hospitalized patients, divided into two groups of nine, received the following dosages of the drugs. The first group took 250 mg of C (equivalent to 50 mg hydrochlorothiazide), 5 mg of A and 100 mg of T; the second received double doses of both A and T but the same dose of C. Each treatment was administered on 2 not necessarily consecutive days, so as to have a total of 6 days of treatment per patient according to a balanced randomized design identical for the two groups. The data were obtained from urine collected during the first 8 h after the drug was administered, and during the following 16 h. A and T showed a significant K-sparing effect (p less than 0.01) only for the second group, and only at the higher dosages were minor effects on the urinary excretion of uric acid, Mg, and Cl noted (p less than 0.05). The association of A or T with C was well tolerated, and no important side effects were observed.