The effect of ampicillin on antibody dependent (ADCC) and lectin induced (LICC) cellular cytotoxicity.

Wasik, M; Skopinska-Rózewska, E; Swiecicka, G

Wasik, M; Skopinska-Rózewska, E; Swiecicka, G.

Arch Immunol Ther Exp (Warsz) ; 29(3): 373-7, 1981.

Article em En | MEDLINE | ID: mdl-7294973

ABSTRACT

ABSTRACT

Peripheral blood mononuclear cells, preincubated in ampicillin-containing media, exhibited a markedly decreased antibody-dependent (ADCC) and lectin-induced (LICC) cellular cytotoxicity against L1210 target cells in 9 out of 20 and 7 out of 13 donors, respectively. Additional experiments revealed that ampicillin effect on ADCC is based upon the blocking of the Fcgamma receptor resynthesis, in the case of their damage occurring in the process of cell separation.

Assuntos

Ampicilina/farmacologia; Citotoxicidade Celular Dependente de Anticorpos/efeitos dos fármacos; Citotoxicidade Imunológica/efeitos dos fármacos; Lectinas/farmacologia; Animais; Separação Celular; Humanos; Leucemia L1210/imunologia; Linfócitos/imunologia; Fito-Hemaglutininas/farmacologia; Coelhos

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Base de dados: MEDLINE Assunto principal: Citotoxicidade Imunológica / Ampicilina / Lectinas / Citotoxicidade Celular Dependente de Anticorpos Limite: Animals / Humans Idioma: En Ano de publicação: 1981 Tipo de documento: Article

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