Graft-versus-host disease in two immunocompetent dogs.
Exp Hematol
; 8(3): 351-60, 1980 Mar.
Article
em En
| MEDLINE
| ID: mdl-7461047
ABSTRACT
Graft-versus-host disease developed in two dogs injected with lymphocytes from BCG immunized donors. The disease was characterized by bone marrow depression, ulcerative enteritis, necrotizing cholangiohepatitis, thymic atrophy, pancreatitis, lymphadenopathy, inflammation of mucous membranes and weight loss. In one of the two dogs repopulation of bone marrow and lymphoid tissue by donor cells was demonstrated by cytogenetics. The development of GVHD was considered unusual because both animals received on immunosuppressive treatment and both responded well to PHA in lymphocyte transformation assays indicating they were immunocompetent. It was hypothesized that stimulation of donor lymphocytes by BCG enhanced their ability to induce a graft-versus-host reaction.
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Base de dados:
MEDLINE
Assunto principal:
Cães
/
Reação Enxerto-Hospedeiro
/
Imunocompetência
Limite:
Animals
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article