Immunophilins in protein folding and immunosuppression.
FASEB J
; 8(6): 391-400, 1994 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-7513288
ABSTRACT
Lymphocyte activation requires the transmission of signals from molecules at the plasma membrane to nuclear signals that regulate gene expression. In recent years, several immunosuppressive compounds have been used as probes to identify important and potentially novel molecules involved in lymphocyte signal transduction processes. The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin have been studied in particular detail. Two distinct classes of immunosuppressant binding proteins have been identified, and collectively termed immunophilins. The cyclophilin family of immunophilins binds CsA, whereas the FK506-binding protein (FKBP) family binds FK506 and rapamycin. This review will discuss both the endogenous functions of immunophilins as well as their roles in mediating immunosuppression.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Dobramento de Proteína
/
Isomerases de Aminoácido
/
Proteínas de Choque Térmico
/
Tolerância Imunológica
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article