Biphenotypic M0 acute myeloid leukemia with trisomy-4.
Leuk Lymphoma
; 14(1-2): 181-4, 1994 Jun.
Article
em En
| MEDLINE
| ID: mdl-7522717
ABSTRACT
We report here a rare case of biphenotypic M0 acute myeloid leukemia (AML) associated with trisomy 4. The literature of trisomy 4 in acute leukemia was reviewed. M2 and M4 AML are the most common FAB subtypes associated with trisomy 4. The clinical course of this entity is generally comparable with other non-trisomy 4 cases of AML. Despite the speculation made when first described, no specific environmental toxin has been found to be associated with this entity. C-kit oncogene has been mapped to chromosome 4 recently, and the role of this proto-oncogene in leukemogenesis of trisomy 4 associated leukemia should be further investigated.
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Base de dados:
MEDLINE
Assunto principal:
Trissomia
/
Cromossomos Humanos Par 4
/
Leucemia Mieloide
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article