Synovial tissue response to treatment with Campath-1H.
Arthritis Rheum
; 38(2): 254-8, 1995 Feb.
Article
em En
| MEDLINE
| ID: mdl-7531440
ABSTRACT
OBJECTIVE:
Therapeutic trials in rheumatoid arthritis with the monoclonal antibody Campath-1H have demonstrated recurrent clinical synovitis in some patients, despite profound depletion of circulating lymphocytes. This study was undertaken to examine the cellular infiltrates in synovial tissue at a time of persistent peripheral lymphopenia.METHODS:
Immunohistochemical staining of synovial tissue and peripheral blood lymphocyte phenotyping.RESULTS:
Synovial tissues from 2 patients with recurrent synovitis after Campath-1H therapy contained significant T lymphocytic infiltrates at a time when circulating T lymphocytes were markedly depleted.CONCLUSION:
These results demonstrate that peripheral blood analysis may not accurately reflect the synovial tissue response to monoclonal antibody therapy.
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Base de dados:
MEDLINE
Assunto principal:
Membrana Sinovial
/
Glicoproteínas
/
Antígenos CD
/
Antígenos de Neoplasias
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article