Down-regulation but not phosphorylation of stathmin is associated with induction of HL60 cell growth arrest and differentiation by physiological agents.
FEBS Lett
; 364(3): 309-13, 1995 May 15.
Article
em En
| MEDLINE
| ID: mdl-7538938
ABSTRACT
Stathmin is a cytosolic phosphoprotein that has an important but, as yet, undefined role in cell proliferation and differentiation. Induction of growth arrest and differentiation of HL60 cells to monocytes by phorbol 12-myristate 13-acetate is associated with rapid phosphorylation of the protein. Stathmin phosphorylation was not seen when HL60 cells were induced to differentiate to monocytes, by 1 alpha, 25-dihydroxyvitamin D3, and to neutrophils, by all-trans retinoic acid and granulocyte colony stimulating factor. In all the above instances, stathmin expression was down-regulated. Thus, increased stathmin phosphorylation is not required for cell growth arrest or differentiation or down-regulation of stathmin expression.
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Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Monócitos
/
Diferenciação Celular
/
Divisão Celular
/
Proteínas dos Microtúbulos
/
Neutrófilos
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article