The PTB domain: a new protein module implicated in signal transduction.
Trends Biochem Sci
; 20(7): 277-80, 1995 Jul.
Article
em En
| MEDLINE
| ID: mdl-7545337
ABSTRACT
Src homology 2 (SH2) domains have been identified in a large number of proteins involved in signal transduction downstream of receptor tyrosine kinases. They allow cytoplasmic signalling proteins to bind specifically to other polypeptides that are phosphorylated on tyrosine in response to growth factor stimulation. A novel phosphotyrosine-binding (PTB) domain has been identified recently in the amino terminus of Shc, an adaptor molecule that appears to be involved in Ras activation PTB domains are longer than SH2 domains, and recognize phosphotyrosine in the context of amino-terminal residues, in contrast to SH2 domains, which recognize them in the context of carboxy-terminal residues.
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Base de dados:
MEDLINE
Assunto principal:
Tirosina
/
Transdução de Sinais
/
Proteínas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article