Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis.
Nat Genet
; 10(3): 313-7, 1995 Jul.
Article
em En
| MEDLINE
| ID: mdl-7545492
ABSTRACT
B10.RIII mice develop chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with the myelin basic protein (MBP) peptide 89-101. The disease is associated with the major histocompatibility complex (MHC) (eae1). We have now investigated the importance of non-MHC regions for the EAE susceptibility in a cross between RIIIS/J and B10.RIII mice which share the MHC region but differ in disease susceptibility. Linkage analysis using microsatellite markers spanning the genome identified a region (eae2) on chromosome 15 which showed linkage to disease (P = 0.0002). Our data also suggest linkage to a second region (eae3) on chromosome 3 (P = 0.0024), and provide evidence for locus interactions between eae2 and eae3. These results provide clues to the genetic basis of multiple sclerosis.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Encefalomielite Autoimune Experimental
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article