Acute dopamine depletion potentiates independent stimulatory and inhibitory D1 DA receptor-mediated control of striatal acetylcholine release in vitro.
Brain Res
; 681(1-2): 209-12, 1995 May 29.
Article
em En
| MEDLINE
| ID: mdl-7552283
ABSTRACT
Fractional release of [3H]ACh was evaluated under basal and evoked conditions in striatal slices from normal and acutely dopamine-depleted adult rats for the influence of D1- and D2-DA receptor agonists. The D1 ligand had no effect on normal slices but DA depletion unmasked two independent but simultaneous supersensitive responses augmentation of K(+)-evoked and inhibition of glutamate-evoked release. The D2 ligand inhibited evoked release in normal slices and this effect was not potentiated. This is a new cholinergic model of acute D1 receptor supersensitivity.
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Base de dados:
MEDLINE
Assunto principal:
Acetilcolina
/
Dopamina
/
Receptores de Dopamina D1
/
Neostriado
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article