The serum concentration of active transforming growth factor-beta is severely depressed in advanced atherosclerosis.
Nat Med
; 1(1): 74-9, 1995 Jan.
Article
em En
| MEDLINE
| ID: mdl-7584958
ABSTRACT
Recent evidence has led us to propose that transforming growth factor-beta (TGF-beta) is a key inhibitor of atherosclerosis. We show here that a population of patients with advanced atherosclerosis all have less active TGF-beta in their sera than patients with normal coronary arteries, with a fivefold difference in average concentration between the two groups. This correlation with atherosclerosis is much stronger than for other known major risk factors and it may therefore have important diagnostic and prognostic significance. Aspirin medication correlates with an increase in active TGF-beta concentration, indicating that therapeutic interventions for TGF-beta are possible.
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Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Fator de Crescimento Transformador beta
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article