The dynamic role of palmitoylation in signal transduction.
Trends Biochem Sci
; 20(5): 181-7, 1995 May.
Article
em En
| MEDLINE
| ID: mdl-7610481
ABSTRACT
Guanine nucleotide binding protein (G protein)-linked receptors, the alpha-subunits of heterotrimeric G proteins and members of the Src family of nonreceptor tyrosine kinases are among many polypeptides that are posttranslationally modified by the addition of palmitate, a long-chain fatty acid. Attachment of palmitate to these proteins is dynamic and may be regulated by their activation. The presence of palmitate appears to play a key role in the membrane localization of either the entire polypeptide or parts of it, and may regulate the interactions of these polypeptides with other proteins.
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Base de dados:
MEDLINE
Assunto principal:
Palmitatos
/
Transdução de Sinais
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article