Acute effects of hypoxaemia and angiotensin II in the human pulmonary vascular bed.
Pulm Pharmacol
; 7(5): 305-10, 1994 Oct.
Article
em En
| MEDLINE
| ID: mdl-7626917
Hypoxaemia and angiotensin II both cause pulmonary vasoconstriction and co-exist as pathophysiological pulmonary pressor stimuli in patients with cor pulmonale. Evidence from animal studies, however, suggests that angiotensin II may modulate the hypoxic pulmonary vasoconstrictor response. We have therefore studied how hypoxaemia and angiotensin II interact in the human pulmonary vascular bed. Eight male volunteers were studied on two occasions. From baseline (T0) onwards, subjects breathed room air at one visit, and on the other, a nitrogen/oxygen mixture which rendered arterial oxygen saturation between 75% and 80%. After 30 min (T30), angiotensin II was infused for a further 30 min (until T60). Mean pulmonary artery pressure (MPAP) and total pulmonary vascular resistance (PVR) were determined by pulsed-wave Doppler echocardiography at T0, T30 and T60. The change in MPAP (delta MPAP) due to hypoxaemia and angiotensin II together was 18.0 +/- 1.3 mmHg, significantly greater than the delta MPAP response to either hypoxaemia alone (13.4 +/- 1.1 mmHg) or angiotensin II alone (10.3 +/- 1.1 mmHg). In terms of change in PVR (delta PVR), the response to hypoxaemia and angiotensin II together (230 +/- 25 dyne.s/cm5) was no different from the response to ANG II alone (214 +/- 31 dyne.s/cm5), although both these were significantly greater than delta PVR with hypoxaemia alone (114 +/- 12 dyne.s/cm5). The delta MPAP and delta PVR responses to angiotensin II were significantly greater when normoxaemic than when hypoxaemic: delta MPAP mean difference 5.6 mmHg (95% confidence interval (CI) 3.0-8.2); delta PVR mean difference 98 dyne.s/cm5 (95% CI 16-181). Angiotensin II therefore produced significantly less pulmonary vasoconstriction when hypoxaemic compared with normoxaemia.(ABSTRACT TRUNCATED AT 250 WORDS)
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Base de dados:
MEDLINE
Assunto principal:
Angiotensina II
/
Circulação Pulmonar
/
Hipóxia
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article