B cell differentiation: role of E2A and Pax5/BSAP transcription factors.
Oncogene
; 11(3): 413-26, 1995 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-7630627
ABSTRACT
Transcriptional regulation of lineage specific genes has the ability to dictate both the proliferative and differentiative potentials of a pluipotent precursor cell. The E2A and Pax5/BSAP genes encode transcription factors which bind to B cell specific promoters and enhancers and guide the development of immature, but committed cells into mature B lymphocytes which express and secrete immunoglobulins. In vitro analysis has consistently suggested that these proteins regulate distinct classes of genes during B cell differentiation; however, recent targeted gene disruption and transgene expression in mice has indicated that these genes may actually be components of a single regulatory mechanism which is essential for both B lymphocyte differentiation and proliferation.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas Nucleares
/
Linfócitos B
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article