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Plasma tetranectin and colorectal cancer.
Høgdall, C K; Christiansen, M; Nørgaard-Pedersen, B; Bentzen, S M; Kronborg, O; Clemmensen, I.
Afiliação
  • Høgdall CK; Dept. of Clinical Biochemistry, Statens Seruminstitut, Copenhagen, Denmark.
Eur J Cancer ; 31A(6): 888-94, 1995 Jun.
Article em En | MEDLINE | ID: mdl-7646916
The prognostic significance of plasma tetranectin (PL-TN) in colorectal cancer was retrospectively examined in 504 patients (80 Dukes' A, 174 Dukes' B, 98 Dukes' C and 152 Dukes' D). Follow-up time was 7-12 years. No significant prognostic variable was found for Dukes' A patients by Cox multivariate analysis. In stage B, PL-TN was the second strongest prognostic variable [relative hazard (RH) = 3.3 for patients with PL-TN < or = 7.5 mg/l]. The other prognostic variables were perineural invasion (RH = 3.7), tumour distance < or = 10 cm from the anal verge (RH = 3.0), postoperative radiotherapy (RH = 2.9) and a high carcinoembryonic antigen (CEA) score (RH = 1.8). In Dukes' C, only CEA score and gender were of prognostic significance. For Dukes' D, PL-TN was the only prognostic variable (RH = 1.7). Testing all patients in one multivariate analysis, Dukes' staging was the strongest and PL-TN the second strongest prognostic variable. The shortened survival for patients with low PL-TN levels is illustrated with lifetables.
Assuntos
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Base de dados: MEDLINE Assunto principal: Proteínas Sanguíneas / Neoplasias Colorretais / Biomarcadores Tumorais / Lectinas Tipo C Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1995 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Proteínas Sanguíneas / Neoplasias Colorretais / Biomarcadores Tumorais / Lectinas Tipo C Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1995 Tipo de documento: Article