Protective effect of Brucella outer membrane complex-bearing liposomes against experimental murine brucellosis.
FEMS Microbiol Lett
; 130(2-3): 231-6, 1995 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-7649445
Liposomes of stable multilamellar type, which previously demonstrated great efficiency in antibiotic transport, were used in this study as transport vehicles of antigenic extracts of Brucella melitensis (HS: complex of lipopolysaccharide/phospholipids/outer membrane proteins). The incorporation of HS into positively charged liposomes produced a protective effect against experimental murine brucellosis when they were administered 1 day before or 2 days after infection, as the number of colony-forming units in the spleen was reduced in relation to the untreated control group (P < 0.01). On the other hand, the use of HS-free or bound in liposomes with negative net charge did not produce a significant effect. Moreover, the incorporation of HS into cationic liposomes eliminated the toxicity of the lipopolysaccharide.
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Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Proteínas da Membrana Bacteriana Externa
/
Brucelose
/
Lipopolissacarídeos
/
Lipossomos
/
Antígenos de Bactérias
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article