4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.

Bakshi, R K; Rasmusson, G H; Patel, G F; Mosley, R T; Chang, B; Ellsworth, K; Harris, G S; Tolman, R L

Bakshi, R K; Rasmusson, G H; Patel, G F; Mosley, R T; Chang, B; Ellsworth, K; Harris, G S; Tolman, R L.

Afiliação

Bakshi RK; Department of Medicinal Chemical Research, Molecular Systems, and Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

J Med Chem ; 38(17): 3189-92, 1995 Aug 18.

Article em En | MEDLINE | ID: mdl-7650670

Assuntos

Inibidores de 5-alfa Redutase; Androstenos/farmacologia; Azasteroides/farmacologia; Androstenos/química; Azasteroides/química; Humanos; Conformação Molecular; Termodinâmica

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Base de dados: MEDLINE Assunto principal: Azasteroides / Inibidores de 5-alfa Redutase / Androstenos Limite: Humans Idioma: En Ano de publicação: 1995 Tipo de documento: Article

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