Stopping a clinical trial very early because of toxicity: summarizing the evidence.
Control Clin Trials
; 14(4): 286-95, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-7689943
ABSTRACT
When a trial is stopped early because of a specific toxicity, it may be important to summarize the statistical evidence for stopping. Such a summary needs to take into account the sequential nature of the stopping rule. We address some practical issues involved in analyzing such toxicity data coming from a trial that was stopped after the fourth patient was evaluated.
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Base de dados:
MEDLINE
Assunto principal:
Ensaios Clínicos como Assunto
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article