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Auditory sensory memory impairment in Alzheimer's disease: an event-related potential study.
Pekkonen, E; Jousmäki, V; Könönen, M; Reinikainen, K; Partanen, J.
Afiliação
  • Pekkonen E; Department of Neurology, University Hospital of Kuopio, Finland.
Neuroreport ; 5(18): 2537-40, 1994 Dec 20.
Article em En | MEDLINE | ID: mdl-7696598
Auditory event-related potentials (ERP) were recorded from 10 healthy older subjects and 9 patients with Alzheimer's disease (AD) to investigate whether auditory sensory memory is impaired in AD. Standard (85%) and deviant (15%) tones were presented in random order with interstimulus intervals (ISI) of 1 s or 3 s in separate blocks. Deviant tones elicited a specific ERP component called mismatch negativity (MMN) which reflects automatic stimulus change detection and thus presumably, the neural basis of sensory memory in audition. The MMN amplitude decreased as a function of the ISI more in the AD group than in the control group. This suggests that the memory trace decays faster in the AD patients than in age-matched healthy controls.
Assuntos
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Base de dados: MEDLINE Assunto principal: Potenciais Evocados Auditivos / Doença de Alzheimer / Audição / Transtornos da Memória Tipo de estudo: Clinical_trials Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1994 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Potenciais Evocados Auditivos / Doença de Alzheimer / Audição / Transtornos da Memória Tipo de estudo: Clinical_trials Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1994 Tipo de documento: Article