Ascitic fluid gamma interferon concentrations and adenosine deaminase activity in tuberculous peritonitis.
Gut
; 36(3): 419-21, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7698702
ABSTRACT
The gamma interferon (gamma-IFN) concentration and the adenosine deaminase (ADA) activity were evaluated in 30 patients with tuberculous peritonitis, 21 patients with ascites due to a malignant disorder, and 41 patients with cirrhosis. The gamma-IFN concentrations were significantly higher (p < 0.0001) in tuberculous peritonitis patients (mean 6.70 U/ml) than in the malignant (mean 3.10 U/ml) and cirrhotic (mean 3.08 U/ml) groups. Use of a cut off value of > or = 3.2 U/ml gave the assay a sensitivity of 93% (25 of 27), a specificity of 98% (54 of 55), positive (P+) and negative (P-) predictive values of 96% and a test accuracy of 96%. The ADA activity was significantly (p < 0.0001) higher in the tuberculous peritonitis group (mean 101.84 U/l) than in the control groups (cirrhosis (mean 13.49 U/l) and malignancy (mean 19.35 U/l)). A cut off value of > 30 U/l gave the ADA test a sensitivity of 93% (26 of 28) a specificity of 96% (51 of 53), a (P+) value of 93%, a (P-) value of 96%, and a test accuracy of 95%. There was a significant (p < 0.0001) correlation (r = 0.72) between ADA activity and gamma-IFN values in patients with tuberculous peritonitis. These results show that a high concentration of gamma-IFN in ascitic fluid is as valuable as the ADA activity in the diagnosis of tuberculous peritonitis. Both are rapid non-invasive diagnostic tests for tuberculous peritonitis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peritonite Tuberculosa
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Líquido Ascítico
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Adenosina Desaminase
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Interferon gama
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article