A case of acute megakaryoblastic leukaemia with t(X;6)(p11.21;q23) having an X chromosome breakpoint within a 450-Kb region which is also disrupted in two classes of solid tumours.
Leukemia
; 9(4): 723-5, 1995 Apr.
Article
em En
| MEDLINE
| ID: mdl-7723409
ABSTRACT
Karyotype analysis of a case of acute megakaryoblastic leukaemia revealed an X;6 translocation as the sole abnormality. Using fluorescence in situ hybridisation on leukaemic metaphases we demonstrated that the breakpoint on the X-chromosome occurred at p11.21, within a region spanned by a YAC probe which has also been found to be disrupted in synovial sarcomas and some papillary renal cell carcinomas.
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Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
/
Leucemia Megacarioblástica Aguda
Limite:
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article