Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120) by rat liver microsomes.
Eur J Drug Metab Pharmacokinet
; 19(4): 303-10, 1994.
Article
em En
| MEDLINE
| ID: mdl-7737231
ABSTRACT
The metabolic fate of central analgesic 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120), was studied in vitro with phenobarbital 3-methylcholanthrene and clofibrate induced rat liver microsomal fractions. The presence of four metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The metabolic pathways involved are oxidative dealkylation, aromatic and alicyclic hydroxylation.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Microssomos Hepáticos
/
Analgésicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article