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Synthesis and anticonvulsant activity of some new 1,1-bis(4-substituted 1,2,4-triazoline-5-thione-3-yl)-2-methylbutanes.
Ergenç, N; Ulusoy, N; Ekinci, A C.
Afiliação
  • Ergenç N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Farmaco ; 50(3): 189-92, 1995 Mar.
Article em En | MEDLINE | ID: mdl-7755867
Several 1,1-bis(4-alkyl/aryl-1,2,4-triazoline-5-thione-3-yl)-2- methylbutane derivatives 13-21 were obtained from the cyclization of mono(1-methylpropyl)malonylbis(4-alkyl/aryl)thiosemicarbazides 2-12 in the presence of sodium hydroxide. Their chemical structures were proven by spectral data (UV, IR, 1H-NMR, MS) and elemental analysis. The anticonvulsant activity of the title compounds were determined against pentylenetetrazole induced seizures. Six of the tested compounds showed anticonvulsant activity (10 to 20% protection).
Assuntos
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Base de dados: MEDLINE Assunto principal: Tionas / Triazóis / Anticonvulsivantes Limite: Animals Idioma: En Ano de publicação: 1995 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Tionas / Triazóis / Anticonvulsivantes Limite: Animals Idioma: En Ano de publicação: 1995 Tipo de documento: Article