Fibroblasts as efficient antigen-presenting cells in lymphoid organs.
Science
; 268(5215): 1343-7, 1995 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-7761853
ABSTRACT
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
/
Linfócitos T Citotóxicos
/
Fibroblastos
/
Vírus da Coriomeningite Linfocítica
/
Tecido Linfoide
/
Células Apresentadoras de Antígenos
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article