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Protein engineering of subtilisins to improve stability in detergent formulations.
von der Osten, C; Branner, S; Hastrup, S; Hedegaard, L; Rasmussen, M D; Bisgård-Frantzen, H; Carlsen, S; Mikkelsen, J M.
Afiliação
  • von der Osten C; Novo-Nordisk A/S, Bagsvaerd, Denmark.
J Biotechnol ; 28(1): 55-68, 1993 Mar.
Article em En | MEDLINE | ID: mdl-7763525
Microbial proteases are used extensively in a large number of industrial processes and most importantly in detergent formulations facilitating the removal of proteinaceous stains. Site-directed mutagenesis has been employed in the construction of subtilisin variants with improved storage and oxidation stabilities. It is shown that in spite of significant structural homology between subtilisins subjected to protein engineering the effects of specific mutations can be quite different. Mutations that stabilize one subtilisin may destabilize another.
Assuntos
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Base de dados: MEDLINE Assunto principal: Subtilisinas / Detergentes Idioma: En Ano de publicação: 1993 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Subtilisinas / Detergentes Idioma: En Ano de publicação: 1993 Tipo de documento: Article