Superoxide radical and toxicity of environmental nickel exposure.
Hum Exp Toxicol
; 14(3): 248-51, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7779454
ABSTRACT
Three nickel compounds were tested for pancreatic, hepatic and osteogenic damage in rats by a single i.m. injection Ni++ (7 mg kg-1). The nickel induced biochemical alterations included significantly increased levels of serum alkaline phosphatase in rats with NiS (75%) and NiO (50%). Amylase and aspartate transaminase were also increased, and lipoperoxide was increased in rats with NiO (5.6-fold) and NiS (3.4-fold). No serum changes were observed with NiCl2. Daily injection of Cu-Zn superoxide dismutase (SOD) conjugated with polyethylene glycol prevented the serum level changes, indicating that superoxide radical is an important intermediate in toxicity of nickel insoluble compounds.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Superóxidos
/
Exposição Ambiental
/
Níquel
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article