HIV-1 modulates the expression of gelatinase A and B in monocytic cells.
Biochem Biophys Res Commun
; 205(2): 1243-9, 1994 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-7802656
ABSTRACT
The levels of mRNA of both gelatinases A and B were dramatically decreased in HIV-infected cells, when compared to uninfected cells. The expression of gelatinase A in HIV-infected cells was selectively increased by tumor necrosis factor (TNF alpha) while the expression of gelatinase B was not affected. In contrast, in uninfected cells TNF alpha down regulated gelatinase B mRNA level, without affecting the gelatinase A. N-acethylcysteine (NAC) increased the levels of mRNA of both gelatinases. The conditioned media from HIV-infected and uninfected cells had comparable level of secreted gelatinase A protein. These data suggest that in monocytic cells different regulatory pathways control gelatinases A and B and that HIV could modulate in vivo the expression of these proteolytic enzymes, critically involved in regulation of invasion of basement membrane.
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Base de dados:
MEDLINE
Assunto principal:
Metaloendopeptidases
/
Monócitos
/
Expressão Gênica
/
Colagenases
/
Gelatinases
Limite:
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article