Inhibition of ecdysone biosynthesis in flies by a hexapeptide isolated from vitellogenic ovaries.
Mol Cell Endocrinol
; 104(1): R1-4, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7821698
ABSTRACT
The only identified insect peptides known to be involved in controlling the biosynthesis of ecdysone, the steroid moulting hormone of arthropods, are the prothoracicotropic hormones (PTTH). These neuropeptides stimulate ecdysone biosynthesis. Recently, a hexapeptide (NPTNLH) with folliculostatic and trypsin modulating activity was isolated from vitellogenic ovaries of the fleshfly Neobellieria bullata. Here we report that the hexapeptide, when tested in vitro on the isolated ring gland of flies, inhibited ecdysone biosynthesis immediately and completely (EC50 = 5 nM). The hexapeptide is the first known factor with 'prothoracicostatic activity' and may form part of the endocrine system that controls ecdysone biosynthesis in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Peptídeos
/
Dípteros
/
Ecdisona
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article