Ultraviolet irradiation for the prevention of graft-versus-host disease and graft rejection in bone marrow transplantation.
Bone Marrow Transplant
; 14(4): 511-6, 1994 Oct.
Article
em En
| MEDLINE
| ID: mdl-7858525
ABSTRACT
This review describes an approach to the prevention of graft-versus-host disease (GVHD) and graft rejection following allogeneic BMT that differs from conventional methods. Ultraviolet (UV) irradiation inhibits the proliferative responses of lymphoid cells to mitogens and alloantigens by inactivation of T lymphocytes and dendritic cells, and in animal models this can prevent both GVHD and graft rejection. It is important that the marrow repopulating capacity of haemopoietic stem cells is not damaged by the irradiation process. We have found that polymorphic microsatellite markers are a sensitive way of assessing the impact of UV irradiation on chimerism after BMT in rodents.
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Base de dados:
MEDLINE
Assunto principal:
Terapia Ultravioleta
/
Transplante de Medula Óssea
/
Rejeição de Enxerto
/
Doença Enxerto-Hospedeiro
Limite:
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article