Myeloperoxidase gene expression in normal granulopoiesis and acute leukemias.
Leuk Lymphoma
; 15(3-4): 209-26, 1994 Oct.
Article
em En
| MEDLINE
| ID: mdl-7866270
ABSTRACT
Myeloperoxidase (MPO) is an abundant heme protein found in granulocytes and monocytes, which plays an important role in host defense against infection. MPO enzyme activity as determined by light microscopic cytochemistry has long been an important marker used in the diagnosis of acute leukemias and other hematopoietic disorders. Recently, MPO expression has been studied at the electron microscopic level, and monoclonal antibodies (mAbs) against MPO protein have been developed. Furthermore, techniques and probes for analysing MPO expression at the RNA level are now available. This has made possible more extensive studies of MPO expression in a wide range of neoplastic and preneoplastic blood disorders. This review will discuss the fundamental biology of MPO as well as recent developments in our understanding of MPO expression in leukemic cells and cell lines of various lineages.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia
/
Peroxidase
/
Granulócitos
/
Hematopoese
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article