Do human atrial 5-HT4 receptors mediate arrhythmias?
Trends Pharmacol Sci
; 15(12): 451-5, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7886817
ABSTRACT
Since their first description five years ago, knowledge about human atrial 5-HT4 receptors has increased considerably. Progress has been facilitated by the advent of selective antagonists with high affinity for human atrial 5-HT4 receptors. The receptors have been detected in both right and left atrium where they mediate increases in contractile force. Human sinoatrial 5-HT4 receptors may mediate the tachycardia caused by 5-HT and cisapride, and 5-HT elicits arrhythmias via 5-HT4 receptors in human atrium. In this article, Alberto Kaumann suggests that 5-HT may be involved in the genesis of atrial fibrillation and associated thromboembolic stroke and that both the arrhythmia and stroke could be prevented by inhibiting 5-HT4 receptors.
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Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Receptores de Serotonina
/
Átrios do Coração
Limite:
Humans
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article