Synthesis, platelet anti-aggregating activity and anti-inflammatory activity of a series of beta-aminoxypropionic acids.
Farmaco
; 49(12): 767-73, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7893333
ABSTRACT
This paper reports the platelet anti-aggregating activity induced by arachidonic acid (AA) and by adenosine-diphosphate (ADP), together with the anti-inflammatory activity evaluated by the carrageenan-induced rat paw edema method, of a series of beta-aminoxypropionic acids which were projected and synthesised as analogues of non-steroidal anti-inflammatory drugs with an arylacetic structure B, in which the aromatic group is substituted by a methyleneaminoxymethylic moiety. Some of the beta-aminoxypropionic acids were evaluated for their capacity to inhibit the cyclooxygenase enzyme by measuring the malondialdehyde (MDA) produced by incubation of sodium arachidonate with platelet-rich plasma (PRP).
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Base de dados:
MEDLINE
Assunto principal:
Propionatos
/
Inibidores da Agregação Plaquetária
/
Agregação Plaquetária
/
Anti-Inflamatórios não Esteroides
Limite:
Animals
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article